The comic tells of the unlife and adventures of the titular character and her similarly odd (if not odder) friends. The story takes place in a small town called Nevermore (taking its name from the same poem as Lenore's namesake "The Raven") and the surrounding wilderness where Lenore's mansion and a nearby graveyard is situated. The primary focus of the graphic novel is dark humor, with many of the stories having twist endings. Common themes are the reinvention of children's songs, games, and nursery rhymes to something more macabre, and subverting all sorts of pop culture icons and cultural figures in to topics of dark comedy. In one story, for instance, Lenore accidentally kills the Easter Bunny. While Lenore's actions often result in the death or injury to those around her, and in various forms of chaos, she is not a malicious character, and often thinks she is doing good - although in recent issues, the character has shown a change in personality.