The League of Super Evil (or "L.O.S.E.") is a group of Super Villains who are plotting to take over their neighborhood in Metrotown and ultimately the world. Their missions usually involve pranks such as gluing a penny to the sidewalk. While all the other citizens in the neighborhood live in suburban houses, L.O.S.E. has a "secret" evil lair. The League is often at odds with other, more "important" super villains such as Skullossus and also tries to evade getting busted by Metrotown's superheroes.